| Product name: |
MLKL (phospho Ser358) rabbit pAb |
| Reactivity: |
Human |
| Alternative Names: |
Mixed lineage kinase domain-like protein |
| Source: |
Rabbit |
| Dilutions: |
IHC-p 1:100-500;IF/ICC 1:100-500;WB 1:500-2000 |
| Immunogen: |
Synthesized peptide derived from human MLKL (phospho S358) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
55kD |
| GeneID: |
197259 |
| Human Swiss-Prot No: |
Q8NB16 |
| Cellular localization: |
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). . |
| Background: |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015], |
