| Product name: |
GRK2 (Phospho-Tyr86) rabbit pAb |
| Reactivity: |
Human; Mouse; Rat |
| Alternative Names: |
Beta-adrenergic receptor kinase 1 (Beta-ARK-1;EC 2.7.11.15;G-protein coupled receptor kinase 2) |
| Source: |
Rabbit |
| Dilutions: |
IHC-p 1:50-200, WB 1:500-2000 |
| Immunogen: |
Synthesized peptide derived from human GRK2 (Phospho-Tyr86) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
75kD |
| GeneID: |
156 |
| Human Swiss-Prot No: |
P25098 |
| Cellular localization: |
Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . |
| Background: |
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008], |
