| Product name: |
FAN1 rabbit pAb |
| Reactivity: |
Human; Mouse |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 |
| Immunogen: |
Synthesized peptide derived from human FAN1 AA range: 801-851 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
112kD |
| GeneID: |
22909 |
| Human Swiss-Prot No: |
Q9Y2M0 |
| Cellular localization: |
Nucleus . Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496). . |
| Background: |
This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5′ flap endonuclease and 5′-3′ exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016], |
