| Product name: |
ITGAV (light chain, Cleaved-Asp891) rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
Integrin alpha-V (Vitronectin receptor subunit alpha;CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen: |
Synthesized peptide derived from human ITGAV (light chain, Cleaved-Asp891) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
17 110kD |
| GeneID: |
3685 |
| Human Swiss-Prot No: |
P06756 |
| Cellular localization: |
Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . |
| Background: |
integrin subunit alpha V(ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015], |
