| Product name: |
TOP2A (Phospho Ser1213) rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
DNA topoisomerase 2-alpha (EC 5.99.1.3;DNA topoisomerase II, alpha isozyme) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from human TOP2A (Phospho Ser1213) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
174kD |
| GeneID: |
7153 |
| Human Swiss-Prot No: |
P11388 |
| Cellular localization: |
Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus . |
| Background: |
catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA.,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.,function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.,PTM:Phosphorylation has no effect on catalytic activity.,similarity:Belongs to the type II topoisomerase family.,subcellular location:Generally located in the nucleoplasm.,subunit:Homodimer. Interacts with COPS5., |
