PDK1 (Phospho Tyr243) rabbit pAb – TO20214
TO20214
Size:Price:
50 µL$148.00
100 µL$248.00
Download

Overview

Product name: PDK1 (Phospho Tyr243) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (EC 2.7.11.2;Pyruvate dehydrogenase kinase isoform 1)
Source: Rabbit
Dilutions: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen: Synthesized peptide derived from human PDHK1 (Phospho Tyr243)
Storage: -20C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 50kD
GeneID: 5163
Human Swiss-Prot No: Q15118
Cellular localization: Mitochondrion matrix .
Background: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013],