| Product name: |
CD86 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
T-lymphocyte activation antigen CD86 (Activation B7-2 antigen;B70;BU63;CTLA-4 counter-receptor B7.2;FUN-1;CD antigen CD86) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000; IF/ICC 1:100-500; ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from human CD86 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
36kD |
| GeneID: |
942 |
| Human Swiss-Prot No: |
P42081 |
| Cellular localization: |
Cell membrane; Single-pass type I membrane protein. |
| Background: |
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011], |
