| Product name: |
MLH1 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1 |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human MLH1. AA range:441-490 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
85kD |
| GeneID: |
4292 |
| Human Swiss-Prot No: |
P40692 |
| Cellular localization: |
Nucleus . Chromosome . Recruited to chromatin in a MCM9-dependent manner. . |
| Background: |
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009], |
