| Product name: |
STK36 rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
STK36; KIAA1278; Serine/threonine-protein kinase 36; Fused homolog |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human STK36. AA range:387-436 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
170kD |
| GeneID: |
27148 |
| Human Swiss-Prot No: |
Q9NRP7 |
| Cellular localization: |
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, cilium axoneme . Low levels also present in the nucleus. . |
| Background: |
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011], |
