| Product name: |
GCS–2 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
GUCY1B2; Guanylate cyclase soluble subunit beta-2; GCS-beta-2 |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human GCS-beta-2. AA range:53-102 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
70kD |
| GeneID: |
2974 |
| Human Swiss-Prot No: |
O75343 |
| Cellular localization: |
Cytoplasm. |
| Background: |
Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an alpha and a beta subunit. The enzyme converts GTP into the second messenger cGMP and plays a major role in the cardiovascular system as a receptor for nitric oxide. Unlike other guanylyl cyclases, GUCY1B2 contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation. |
