| Product name: |
CD138 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
SDC1; SDC; Syndecan-1; SYND1; CD138 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human SDC1. AA range:191-240 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
34kD |
| GeneID: |
6382 |
| Human Swiss-Prot No: |
P18827 |
| Cellular localization: |
Membrane ; Single-pass type I membrane protein . Secreted . Secreted, extracellular exosome . Shedding of the ectodomain produces a soluble form. . |
| Background: |
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008], |
