| Product name: |
SR-2A rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
HTR2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. Immunofluorescence: 1/200 – 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human 5-HT-2A. AA range:422-471 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
53kD |
| GeneID: |
3356 |
| Human Swiss-Prot No: |
P28223 |
| Cellular localization: |
Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Cell junction, synapse, presynapse . |
| Background: |
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009], |
