| Product name: |
ALS rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
IGFALS; ALS; Insulin-like growth factor-binding protein complex acid labile subunit; ALS |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human IGFALS. AA range:303-352 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
66kD |
| GeneID: |
3483 |
| Human Swiss-Prot No: |
P35858 |
| Cellular localization: |
Secreted, extracellular space. |
| Background: |
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009], |
