| Product name: |
GDF-8 rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
MSTN; GDF8; Growth/differentiation factor 8; GDF-8; Myostatin |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human GDF-8. AA range:38-87 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
43kD |
| GeneID: |
2660 |
| Human Swiss-Prot No: |
O14793 |
| Cellular localization: |
Secreted . |
| Background: |
myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016], |
