| Product name: |
Myosin IXb rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
MYO9B; MYR5; Unconventional myosin-IXb; Unconventional myosin-9b |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human MYO9B. AA range:304-353 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
250kD |
| GeneID: |
4650 |
| Human Swiss-Prot No: |
Q13459 |
| Cellular localization: |
Cytoplasm, cell cortex . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. . |
| Background: |
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
