| Product name: |
Pim-1 (phospho Tyr309) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
PIM1; Serine/threonine-protein kinase pim-1 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human Pim-1 around the phosphorylation site of Tyr309. AA range:281-330 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
45kD |
| GeneID: |
5292 |
| Human Swiss-Prot No: |
P11309 |
| Cellular localization: |
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane. |
| Background: |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011], |
