| Product name: |
CLN6 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
CLN6; Ceroid-lipofuscinosis neuronal protein 6; Protein CLN6 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human CLN6. AA range:221-270 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
40kD |
| GeneID: |
54982 |
| Human Swiss-Prot No: |
Q9NWW5 |
| Cellular localization: |
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum . |
| Background: |
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008], |
