| Product name: |
NBK (phospho Thr33) rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
BIK; NBK; Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human BIK around the phosphorylation site of Thr33. AA range:18-67 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
30kD |
| GeneID: |
638 |
| Human Swiss-Prot No: |
Q13323 |
| Cellular localization: |
Endomembrane system; Single-pass membrane protein. Mitochondrion membrane ; Single-pass membrane protein . Around the nuclear envelope, and in cytoplasmic membranes. |
| Background: |
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011], |
