| Product name: |
Blk (phospho Tyr501) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
BLK; Tyrosine-protein kinase Blk; B lymphocyte kinase; p55-Blk |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human BLK around the phosphorylation site of Tyr501. AA range:456-505 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
58kD |
| GeneID: |
640 |
| Human Swiss-Prot No: |
P51451 |
| Cellular localization: |
Cell membrane ; Lipid-anchor . Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). . |
| Background: |
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010], |
