| Product name: |
Stat4 (phospho Tyr693) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
STAT4; Signal transducer and activator of transcription 4 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human Stat4 (phospho Tyr693) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
85kD |
| GeneID: |
6775 |
| Human Swiss-Prot No: |
Q14765 |
| Cellular localization: |
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation. |
| Background: |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011], |
