Tie-1 rabbit pAb – TO7394
TO7394
Size:Price:
50 µL$148.00
100 µL$248.00

Overview

Product name: Tie-1 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: TIE1; TIE; Tyrosine-protein kinase receptor Tie-1
Source: Rabbit
Dilutions: IHC-p: 100-300.Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human TIE1. AA range:851-900
Storage: -20C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 130kD
GeneID: 7075
Human Swiss-Prot No: P35590
Cellular localization: Cell membrane ; Single-pass type I membrane protein .
Background: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],