| Product name: |
Troponin I-C (phospho Ser43) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
TNNI3; TNNC1; Troponin I; cardiac muscle; Cardiac troponin I |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human TNNI3 around the phosphorylation site of Ser43. AA range:11-60 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
26kD |
| GeneID: |
7137 |
| Human Swiss-Prot No: |
P19429 |
| Cellular localization: |
cytosol,troponin complex,sarcomere, |
| Background: |
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008], |
