| Product name: |
Neurocalcin rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
NCALD; Neurocalcin-delta |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen: |
Synthesized peptide derived from Neurocalcin . at AA range: 370-450 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
22kD |
| GeneID: |
83988 |
| Human Swiss-Prot No: |
P61601 |
| Cellular localization: |
intracellular,cytosol,clathrin coat of trans-Golgi network vesicle,extracellular exosome, |
| Background: |
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008], |
