| Product name: |
PERK rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK |
| Source: |
Rabbit |
| Dilutions: |
IF: 1:50-200 Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human EIF2AK3. AA range:947-996 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
125kD |
| GeneID: |
9451 |
| Human Swiss-Prot No: |
Q9NZJ5 |
| Cellular localization: |
Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Background: |
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015], |
