| Product name: |
Perforin 1 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000, IHC 1:50-200, ELISA 1:10000-20000 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the C-terminal region of human PRF1. AA range:451-500 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
61kD |
| GeneID: |
5551 |
| Human Swiss-Prot No: |
P14222 |
| Cellular localization: |
Cytolytic granule . Secreted. Cell membrane ; Multi-pass membrane protein . Endosome lumen . Stored in cytolytic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell (PubMed:20038786). Inserts into the cell membrane of target cells and forms pores (PubMed:20889983). Membrane insertion and pore formation requires a major conformation change (PubMed:20889983). May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes (PubMed:20038786). . |
| Background: |
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008], |
