| Product name: |
MIB1 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
MIB1 DIP1 KIAA1323 ZZANK2 |
| Source: |
Rabbit |
| Dilutions: |
IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 901-950 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
130kD |
| GeneID: |
57534 |
| Human Swiss-Prot No: |
Q86YT6 |
| Cellular localization: |
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cell membrane . Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. . |
| Background: |
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013], |
