| Product name: |
Tcl1 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000, ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 30-110 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
13kD |
| GeneID: |
8115 |
| Human Swiss-Prot No: |
P56279 |
| Cellular localization: |
Cytoplasm . Nucleus . Microsome . Endoplasmic reticulum . Microsomal fraction. |
| Background: |
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010], |
