| Product name: |
Tensin-1 (phospho Tyr1326) rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
TNS1; TNS; Tensin-1 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human Tensin-1 (phospho Tyr1326) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
185kD |
| GeneID: |
7145 |
| Human Swiss-Prot No: |
Q9HBL0 |
| Cellular localization: |
Cell surface . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner. |
| Background: |
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015], |
