| Product name: |
Dsg1 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
Desmoglein-1 (Cadherin family member 4;Desmosomal glycoprotein 1;DG1;DGI;Pemphigus foliaceus antigen) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 30-90 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
160kD |
| GeneID: |
1828 |
| Human Swiss-Prot No: |
Q02413 |
| Cellular localization: |
Cell membrane ; Single-pass type I membrane protein . Cell junction, desmosome. |
| Background: |
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015], |
