| Product name: |
MLK3 (phospho Ser674) rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human MLK3 (phospho Ser674) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
93kD |
| GeneID: |
4296 |
| Human Swiss-Prot No: |
Q16584 |
| Cellular localization: |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent. |
| Background: |
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008], |
