| Product name: |
MYBPC3 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen: |
Synthesized peptide derived from human MYBPC3 Polyclonal |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
140kD |
| GeneID: |
4607 |
| Human Swiss-Prot No: |
Q14896 |
| Cellular localization: |
cytosol,striated muscle myosin thick filament,C zone,sarcomere,A band, |
| Background: |
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008], |
