| Product name: |
SKAP1 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from part region of human protein |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
39kD |
| GeneID: |
8631 |
| Human Swiss-Prot No: |
Q86WV1 |
| Cellular localization: |
Cytoplasm . Nucleus . Cell membrane . Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. . |
| Background: |
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008], |
