| Product name: |
AT2B2 rabbit pAb |
| Reactivity: |
Human;Rat |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from human protein . at AA range: 250-330 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
136kD |
| GeneID: |
491 |
| Human Swiss-Prot No: |
Q01814 |
| Cellular localization: |
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse .; [Isoform WA]: Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform WB]: Apical cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform XB]: Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform ZA]: Basolateral cell membrane ; Multi-pass membrane protein .; [Isoform ZB]: Basolateral cell membrane ; Multi-pass membrane protein . |
| Background: |
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced tran |
