| Product name: |
Rb (phospho Ser612) rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110 |
| Source: |
Rabbit |
| Dilutions: |
Immunohistochemistry: 1/100 – 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human Rb (phospho Ser612) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
106kD |
| GeneID: |
5925 |
| Human Swiss-Prot No: |
P06400 |
| Cellular localization: |
Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. . |
| Background: |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008], |
