| Product name: |
Fatty Acid Synthase rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
FASN; FAS; Fatty acid synthase |
| Source: |
Rabbit |
| Dilutions: |
IHC-p: 100-300.Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human Fatty Acid Synthase. AA range:1478-1527 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
273kD |
| GeneID: |
2194 |
| Human Swiss-Prot No: |
P49327 |
| Cellular localization: |
Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Background: |
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008], |
