| Product name: |
PUMA rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
23kD |
| GeneID: |
27113 |
| Human Swiss-Prot No: |
Q9BXH1 |
| Cellular localization: |
Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release. |
| Background: |
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011], |
