| Product name: |
SCN8A rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from part region of human protein |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
217kD |
| GeneID: |
6334 |
| Human Swiss-Prot No: |
Q9UQD0 |
| Cellular localization: |
Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Mainly localizes to the axon initial segment. .; [Isoform 5]: Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane. |
| Background: |
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
