| Product name: |
OCLN rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications. |
| Immunogen: |
Synthesized peptide derived from part region of human protein. AA350-400 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
57kD |
| GeneID: |
100506658 |
| Human Swiss-Prot No: |
Q16625 |
| Cellular localization: |
Cell membrane ; Multi-pass membrane protein . Cell junction, tight junction . |
| Background: |
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011], |
