| Product name: |
CaMK2 (Phospho-Thr286) Antibody |
| Reactivity: |
Human; Mouse; Rat |
| Alternative Names: |
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta;CaMK-II subunit delta;EC 2.7.11.17) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000, ELISA(peptide)1:5000-20000 |
| Immunogen: |
Synthesized pospho peptide derived from human CaMK2 (Phospho-Thr286) |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
54kD |
| GeneID: |
817 |
| Human Swiss-Prot No: |
Q9UQM7/Q13557 |
| Cellular localization: |
Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, dendrite . Postsynaptic lipid rafts. . |
| Background: |
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008], |
