| Product name: |
RUBIC rabbit pAb |
| Reactivity: |
Human; Mouse |
| Alternative Names: |
Run domain Beclin-1 interacting and cystein-rich containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000 |
| Immunogen: |
Synthesized peptide derived from human RUBIC AA range: 868-918 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
105kD |
| GeneID: |
9711 |
| Human Swiss-Prot No: |
Q92622 |
| Cellular localization: |
Late endosome . Lysosome . Early endosome . Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus. |
| Background: |
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014], |
