Cell cycle checkpoint protein RAD1 (hRAD1;EC 3.1.11.2;DNA repair exonuclease rad1 homolog;Rad1-like DNA damage checkpoint protein)
Source:
Rabbit
Dilutions:
IHC-p 1:50-200, WB 1:500-2000
Immunogen:
Synthesized peptide derived from human RAD1
Storage:
-20C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
32kD
GeneID:
5810
Human Swiss-Prot No:
O60671
Cellular localization:
Nucleus .
Background:
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009],