| Product name: |
ASPP1 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) |
| Source: |
Rabbit |
| Dilutions: |
IHC-p 1:50-200, ELISA 1:10000-20000 |
| Immunogen: |
Synthetic peptide from human protein at AA range: 630-680 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| GeneID: |
23368 |
| Human Swiss-Prot No: |
Q96KQ4 |
| Cellular localization: |
Cytoplasm . Nucleus . Predominantly cytoplasmic. Some fraction is nuclear. |
| Background: |
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008], |
