| Product name: |
ATG13 Rabbit pAb |
| Reactivity: |
Human; Mouse;Rat |
| Alternative Names: |
Autophagy-related protein 13 |
| Source: |
Rabbit |
| Dilutions: |
IHC-p1:50-200 ,WB 1:1000-2000 |
| Immunogen: |
Synthesized peptide derived from human ATG13 AA range: 182-232 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
72kD |
| GeneID: |
9776 |
| Human Swiss-Prot No: |
O75143 |
| Cellular localization: |
Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. . |
| Background: |
Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions. |
