| Product name: |
Axl rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
AXL; UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
Synthesized peptide derived from Axl . at AA range: 630-710 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
130kD |
| GeneID: |
558 |
| Human Swiss-Prot No: |
P30530 |
| Cellular localization: |
Cell membrane ; Single-pass type I membrane protein . |
| Background: |
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013], |
