| Product name: |
Bestrophin-1 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse |
| Alternative Names: |
Bestrophin-1 (TU15B;Vitelliform macular dystrophy protein 2) |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: |
Synthetic Peptide of Bestrophin-1 AA range: 161-211 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
67kD |
| GeneID: |
7439 |
| Human Swiss-Prot No: |
O76090 |
| Cellular localization: |
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . |
| Background: |
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008], |
