| Product name: |
CABP rabbit pAb |
| Reactivity: |
Rat;Mouse |
| Alternative Names: |
Calcium-binding protein 1 (CaBP1;Calbrain;Caldendrin) |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen: |
Synthetic Peptide of CABP |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
40kD |
| GeneID: |
9478 |
| Human Swiss-Prot No: |
Q9NZU7 |
| Cellular localization: |
Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell membrane ; Lipid-anchor; Cytoplasmic side. Golgi apparatus . Cell junction, synapse, postsynaptic density . L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane. .; [Isoform L-CaBP1]: Cytoplasm, cytoskeleton . L-CaBP1 is associated most likely with the cytoskeletal structures. .; [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane ; Lipid-anchor . S-CaBP1 is localized at or near the plasma membrane. |
| Background: |
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012], |
