| Product name: |
Cadherin-23 rabbit pAb |
| Reactivity: |
Human;Mouse;Rat |
| Alternative Names: |
CDH23; KIAA1774; KIAA1812; Cadherin-23; Otocadherin |
| Source: |
Rabbit |
| Dilutions: |
Immunofluorescence: 1/200 – 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human CDH23. AA range:61-110 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
370kD |
| GeneID: |
64072 |
| Human Swiss-Prot No: |
Q9H251 |
| Cellular localization: |
Cell membrane ; Single-pass type I membrane protein . |
| Background: |
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013], |
