| Product name: |
CD141 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
THBD; THRM; Thrombomodulin; TM; Fetomodulin; CD antigen CD141 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human THBD. AA range:526-575 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
60kD |
| GeneID: |
7056 |
| Human Swiss-Prot No: |
P07204 |
| Cellular localization: |
Membrane; Single-pass type I membrane protein. |
| Background: |
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008], |
