| Product name: |
CD43 rabbit pAb |
| Reactivity: |
Human;Rat;Mouse; |
| Alternative Names: |
Leukosialin (Galactoglycoprotein;GALGP;Leukocyte sialoglycoprotein;Sialophorin;CD antigen CD43) |
| Source: |
Rabbit |
| Dilutions: |
WB 1:1000-2000 ELISA 1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from human CD43 AA range: 1-80 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
44kD |
| GeneID: |
6693 |
| Human Swiss-Prot No: |
P16150 |
| Cellular localization: |
Membrane ; Single-pass type I membrane protein . Cell projection, microvillus . Cell projection, uropodium . Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). .; [CD43 cytoplasmic tail]: Nucleus . Nucleus, PML body . The sumoylated form localizes to the PML body. . |
| Background: |
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011], |
