| Product name: |
Cdc23 rabbit pAb |
| Reactivity: |
Human;Mouse;Monkey |
| Alternative Names: |
CDC23; ANAPC8; Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8 |
| Source: |
Rabbit |
| Dilutions: |
Western Blot: 1/500 – 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300 |
| Storage: |
-20C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
69kD |
| GeneID: |
8697 |
| Human Swiss-Prot No: |
Q9UJX2 |
| Cellular localization: |
intracellular,nucleoplasm,anaphase-promoting complex,cytosol, |
| Background: |
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008], |
